Medroxyprogesterone acetate impairs human dendritic cell activation and function

Medroxyprogesterone acetate impairs human dendritic cell activation and function.

STUDY QUESTION Does medroxyprogesterone acetate (MPA) impair human dendritic cell (DC) activation and function? SUMMARY ANSWER In vitro MPA treatment suppressed expression of CD40 and CD80 by human primary DCs responding to Toll-like receptor 3 (TLR3) agonist stimulation (i.e. DC activation). Moreover, this MPA-mediated decrease in CD40 expression impaired DC capacity to stimulate T cell prol...

Corticosterone impairs dendritic cell maturation and function.

Dendritic cells (DC) play a critical role in initiating and directing adaptive immune responses against pathogens and tumours. Immature DC are thought to act as sentinels in peripheral tissues where their main function is to capture antigen at sites of infection, whereas mature DC are highly efficient at priming T-cell-mediated immune responses against infectious pathogens. The DC maturation pr...

Mucosal Herpes Simplex Virus Type Administered Medroxyprogesterone Acetate Development Are Impaired among Mice Dendritic Cell Activation and Memory Cell

Subcutaneous depo-medroxyprogesterone acetate.

To cite: Cameron S. Journal of Family Planning and Reproductive Health Care 2013;39:75–77. INTRODUCTION Since 2004, a micronised formulation of depo-medroxyprogesterone acetate (DMPA) that is delivered as a subcutaneous injection has been available. It is currently in clinical use in the USA and in nine countries throughout Europe. As of March 2013 this product is being marketed in the UK as Sa...

Injectable Medroxyprogesterone Acetate for Contraception

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